LILLY RESEARCH LABORATORIES
Lilly Research Laboratories Collaborative Access Team (LRL-CAT)
offers Express Crystallography,
a MAIL-IN protein crystallography service at the Advanced Photon Source
(the most intense x-ray source in the U.S.).
Under this program, researchers can obtain data from the X-ray facilities
at LRL-CAT. Crystals are screened and data collected based on the
To learn more about the LRL-CAT Express Crystallography Service,
Contact us: email@example.com
For information on the APS General User Program,
Advanced Photon Source
9700 S. Cass Ave., Bldg. 438A Sector 31, Argonne, IL 60439
630-252-0820 (Phone) | 630-252-0835 (Facsimile)
LRL-CAT, the X-ray Synchrotron Beamline operated by Eli Lilly &
offers Express Crystallography, a full-service mail-in program in protein
crystallography to industrial, government and academic users of the Advanced
Photon Source at Argonne National Laboratory. Through this program, researchers
have the same access to the beamline that has been available within the
company since 2001.Monochromator: Kohzu HLD-15 Double Crystal
Crystals: Silicon(111) (2d = 4.1188 Å)
Energy range (beamline, standard configuration): 5.0 - 22 keV (1.4
- 0.90 Å)
Energy range (monochromator): 5.0 - 22 keV
Energy resolution: ~0.01 % (FWHM)
Focused beam size: ~0.110 mm x 0.08 mm
Flux at sample position (Se K edge, 1st harmonic of undulator): 5.2 x
1012 (photons/sec, measured with Si pin diode)
Detector: Pilatus3 S 6M
The beamline staff uses automated tools at LRL-CAT to evaluate protein
crystals. The automated system for crystal evaluation (scoring) has been
in operation for almost 13 years and has analyzed diffraction from more
than 170,000 crystals. The system has improved the yield of data,
continually demonstrating that crystals whose diffraction appears
suboptimal can provide useful and even excellent data.
Samples sent to LRL-CAT are identified by barcodes supplied by the
beamline. The barcodes allow all crystals in the program to be tracked
while at LRL-CAT. Equivalent crystals are linked together in the database
used by the beamline. This feature, combined with automated scoring,
permits LRL-CAT to reliably select the best crystals for
Interested users should examine the procedures for preparing and
identifying crystals at LRL-CAT, several of which are unique to the
beamline. Please contact LRL-CAT at firstname.lastname@example.org for a copy of these
procedures or click here.
All proprietary requests will require contract agreements. LRL-CAT offers a Fee for Service or Long Term Program. Contact us for program details.
All non-proprietary requests for data collection at LRL-CAT are handled as rapid access
proposals through the General User Program of the Advanced Photon Source.
Proposals may be sent to the APS at any time. Once a proposal has been
submitted and all safety documentation provided, samples can be run
quickly when the APS is operational. The typical turn-around for datasets
is within 5 days.
LRL-CAT - Macromolecular Crystallography - Technical capabilities
Copyright © 2020 Eli Lilly and Company. All rights reserved.
Last updated July-2021